Background/Aim: Tridax procumbens (Linn) (Asteraceae) is one of the herbs widely distributed in many parts of the world. Its leaves have long been used for the treatment of hypertension in Nigeria. Previous studies have shown that aqueous leaves of Tridax procumbens extract (TPE) lowers blood pressure through endothelium dependent and -independent mechanism in the aortic rings isolated from nomotensive rats. The aim of the present study was to further investigate mechanisms of TPE induced relaxation in aortic artery by assessing its mechanistic interactions with nitric oxide (NO) synthase, cGMP and cAMP. Materials and Methods: The aortic artery isolated from healthy, young adult nomotensive Wistar albino rats (250-300g) were pre-contracted with phenylephrine (10-7M) and KCl (60mM) and were treated with various concentration of aqueous extract of TPE (0.5- 9.0mg/ml). The changes in arterial tension were recorded using Ugo Basile model 7004 coupled to Data capsule acquisition system Model 17400. The interaction between TPE with cAMP and cGMP inhibitors was also evaluated. Results: The results showed that the TPE (0.5- 9.0mg/ml) significantly (p
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