Abstract

Objective: We sought to evaluate whether there is a gender difference for IRIS IQ200 test results as rapid diagnostic test in rouling out culture positivity in infants in a routine hospital laboratory.
Methodology: This retrospective cohort study utilized data from 2159 unselected consecutive patients aged 1 month to 1 year, who attended the Sevket Yilmaz Research and Education Hospital from January to December 2014 and received both urinalysis and culture for suspected UTI. A sample was considered culture-positive if it contained a pure culture of ≥ 50,000 104 CFU/mL. 272 patients, 39 culture positive and 233 culture negative females (median age 6 months), and 280 male patients, 28 culture positive and 252 culture negative, (median age 4 months) were evaluated.
Results: Nitrite alone had a PPV of 95% and an NPV of 90.9% in the infant group. PPV and SP were 100% in male infants. A positive leukocyte count (≥4 cells/HPF) had a specificity of 90%, a PPV of 46.6% and an NPV of 94.5% in infants, which was 94.3 in boys. LE alone had higher specifity (95.1%), PPV (53.8%) and NPV (94.4%) in boys compared to girls, 89.2%, 50.0% and 94.4%
Conclusions: The results of urine tests should not be used alone for the diagnosis of UTI in infant without gender difference.

Key words: Urinary Tract Infections, Gender, Leukocytes, Infant, Microscopy