Home|Journals|Articles by Year|Audio Abstracts
 

Original Article

J App Pharm Sci. 2016; 6(4): 001-005


Chemical constituents and cytotoxic effect from the barks of Goniothalamus chinensis Merr. & Chun. growing in Vietnam

Loi Vu Duc, Tung Bui Thanh, Hai Nguyen Thanh, Vung Nguyen Tien.




Abstract

Goniothalamus chinensis Merr. & Chun is a medicinal plant which has cytotoxicity, antitumor, antifungal, antimalaria and antituberculosis and antioxidant activity. The styryl-lactone, alkaloid and acetogenin are the main group compounds in species of Goniothalamus. In this study, we aimed to investigate phytochemical and cytotoxic effect of compounds from bark of Goniothalamus chinensis Merr. & Chun. The bark of Goniothalamus chinensis Merr. & Chun grown in Vietnam was extracted by methanol. Three compounds were isolated using on Sephadex LH-20 and preparative glass-backed TLC plates. The compound's structure were characterized on the basis of spectroscopic data and by comparing their physicochemical and spectral data with those published in literatures. The cytotoxicity of three compounds was evaluated against four cancer cell lines: epithelial cancer (KB), liver (Hep G2); breast cancer (MCF-7) and lung (LU-1). We have been isolated three compounds. Their structures were identified as Goniothalamin (1), Aristolactam BII (2),3-Methyl-1H-benz[f]indole-4,9-dione (3). Isolated compounds were tested cytotoxic activity against different cancer cell lines. The compound 1 demonstrated the highest potency against the epithelial cancer cell line with an IC50 of 4.18 ± 0.60µg/mL. Other compounds have weak cytotoxic activity.

Key words: Goniothalamus chinensis Merr. & Chun, cytotoxicity, cancer cell line






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.