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Effect of topical sodium fusidate, calcium mupirocin and papain—urea on wound healing in diabetic wistar rats

Smita Shenoy, Raghu Murthy, Lalit Mohan, Amoolya Gowda, Venu Madhav Nelluri.


Abstract

Background: Poor wound healing is a complication of diabetes mellitus. Various agents have been used to promote wound healing in diabetic patients. Papain urea is used as a sloughing agent, whereas sodium fusidate and calcium mupirocin are used as topical antimicrobials for wounds in diabetics.

Aims and Objective: To evaluate effect of topical sodium fusidate, calcium mupirocin, and papain–urea on wound healing in diabetic wistar rats.

Materials and Methods: Incision and excision wound models were used. Each model had five groups of six rats each and one group was nondiabetic control. Diabetes was induced in the remaining four groups, one diabetic control, and three test groups in each model, using streptozotocin (30 mg/kg intraperitoneally). Wounds were made in diabetic rats with blood glucose levels of more than 250 mg/dL. Paraffin ointment base was applied to wounds of nondiabetic and diabetic control, whereas sodium fusidate, mupirocin, and papain–urea were applied topically to three test groups, respectively, in each model.

Result: In sodium fusidate-treated group, there was a significant increase in breaking strength of incision wound, contraction rate, and hydroxyproline content of excision wound as compared to diabetic control group. There was significant decrease in period of epithelization in sodium fusidate-treated group compared to diabetic control group. There was no significant alteration in wound healing by mupirocin and papain–urea.

Conclusion: Topical application of sodium fusidate promoted wound healing in diabetic rats.

Key words: Breaking strength; Epithelization; Wound contraction; Streptozotocin






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