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Vitamin E improves quality of life in patients with alcoholic liver disease

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar.




Abstract

Background: Alcoholic Liver Disease (ALD) is a major cause of morbidity and mortality not only in India but also worldwide. The evidence that oxidative stress is involved in the pathogenesis of ALD and Vitamin E deficiency being well documented in patients of ALD, an antioxidant like Vitamin E could likely be beneficial in patients with ALD.

Aims and Objectives: To study the effect of Vitamin E supplementation over a period of 12 weeks on Quality of life of patients with ALD.

Materials and Methods: This is a prospective, open labeled, randomized study involving a total of 30 adult patients diagnosed with ALD who were randomized into two groups of 15 each and were designated as group A (received standard treatment) and group B (received Vitamin E along with standard treatment). Quality of life was assessed by using Chronic Liver Disease Questionnaire (CLDQ) through its various domains along with global score, as a baseline measure before and after completing the treatment period of three months in each group and the scores were recorded and compared.

Result: In group A, scores in CLDQ-FA, CLDQ-AC domains and CLDQ-Global showed a statistically highly significant (P

Key words: Chronic liver disease questionnaire (CLDQ); vitamin e; alcoholic liver disease; antioxidant






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