Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Article

J App Pharm Sci. 2016; 6(10): 113-123

Protective Effects of Solanum erianthum D. Don Leaf Extract on Lead-Induced Toxicity in Adult Wistar Rats

Olusegun Babalola, John Agbi, Adeleke Badiora, Oladayo Areola.

The possible protective effects of the most potent fraction of Solanum erianthum ethanol leaf extract on lead-induced toxicity in adult wistar rats were investigated. Phytochemical constituents, antioxidant and membrane stabilizing activities of the ethanol extract and its fractions were determined using standard procedures. Acute and sub-chronic oral toxicity studies were carried out. The blood samples, liver, and kidney were collected for the estimation of biochemical and organ parameters, and histomorphological studies. The ethyl acetate fraction had the highest antioxidant activities and high membrane stabilizing potentials when compared to the crude extract and other fractions. Significant elevations were observed in plasma albumin, creatinine and urea levels in group treated with lead only. The activities of plasma ALT and AST were significantly increased in group treated with lead alone. Treatment with ethyl acetate fraction significantly decreased (< 0.05) the elevated ALT, AST, urea and creatinine levels. The histology evidence showed progressive degeneration of the liver and kidney tissues in lead treated groups while the administration of S. erianthum showed appreciable degrees of protection to both the liver and kidney. The study concluded that ethyl acetate fraction of S. erianthum has protective effects against lead-induced toxicity in adult Wistar rats.

Key words: Keywords: Lead-induced toxicity, Solanum erianthum, ethyl acetate fraction, acute toxicity, sub-chronic toxicity, histology

Similar Articles

Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease.
Hernandez-Sapiens MA, Reza-Zaldívar EE, Márquez-Aguirre AL, Gómez-Pinedo U, Matias-Guiu J, Cevallos RR, Mateos-Díaz JC, Sánchez-González VJ, Canales-Aguirre AA
Neural regeneration research. 2022; 17(1): 31-37

Optogenetic activation of intracellular signaling based on light-inducible protein-protein homo-interactions.
Huang P, Zhao Z, Duan L
Neural regeneration research. 2022; 17(1): 25-30

Dendritic spine density changes and homeostatic synaptic scaling: a meta-analysis of animal studies.
Moulin TC, Rayêe D, Schiöth HB
Neural regeneration research. 2022; 17(1): 20-24

extract promotes M2 polarization and reduces oligomeric amyloid-β-induced inflammatory reactions in microglial cells.
Sun ZQ, Liu JF, Luo W, Wong CH, So KF, Hu Y, Chiu K
Neural regeneration research. 2022; 17(1): 203-209

Neuroprotective effects of Alda-1 mitigate spinal cord injury in mice: involvement of Alda-1-induced ALDH2 activation-mediated suppression of reactive aldehyde mechanisms.
Khan M, Qiao F, Kumar P, Touhidul Islam SM, Singh AK, Won J, Singh I
Neural regeneration research. 2022; 17(1): 185-193

Full-text options

Add your Article(s) to Indexes
• CiteIndex: Articles & Statistics

American Journal of Diagnostic Imaging


Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.