Atopic dermatitis (AD) is an inflammatory skin disease which characterized by chronic recidive skin rash and accompanied by complaints of pruritus. Chronic pruritus is reported to occur in 87-100% of AD patients and often affecting patientÂ’s quality of life. Management of chronic pruritus with antihistamines in AD is often ineffective, thus different pruritogens are considered to undergone the histamine-independent itch pathway.
Key words: Chronic pruritus, atopic dermatitis, histamine-dependent, histamine-independent pathway
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