Abstract

Objective: To explore nephropathological association in diabetic UTIs based on neutrophil percentage to albumin ratio (NPAR) as an integrated biomarker.
Methodology: This sectional cross-sectional retrospective study included 102 patients (diabetic UTIs patients n=78, healthy controls n=24) with 60 females and 42 males with UTIs seen at Shaikh Zayed Hospital, Lahore. Clinical confounders (e.g., HbA1c, fasting glucose, dysuria, urgent urine frequency, chills, hematuria, and frequent flank pain (pyelonephritis) were assessed along with an integrated biomarker NPAR (ml/g) analysis. Statistical analyses were performed via SPSS 26.0 using T-test and Pearson Correlation.
Results: The mean age of participants (n=102) was 50.5±5.29 years, with 60 (59%) females and 42 (41%) males. Diabetic UTIs confounders were recorded as HbA1c (11.10±1.61%), Fasting Glucose levels (8.36± 0.92 mmol/L), dysuria (82%), frequency (72%), chills (49%), hematuria (46%), suprapubic discomfort (52%) and frequent flank (pyelonephritis) pain (32%). Mean NPAR had (2.07±0.04) a significant correlation (Pearson coefficient r=0.51) between NPAR and severity of UTIs (p

Key words: Nephropathology, urinary tract infections, diabetes, neutrophil percentage to albumin ratio (NPAR), infection diagnostics.