Objectives: Most ovarian surface epithelial tumors emerge from a background of Müllerian metaplasias. The incidence and extent of Müllerian metaplasias were examined in ovarian surface epithelial tumors.
Methods: The incidence of Müllerian metaplasias was evaluated according to the presence of the metaplasias in all cases. The extent of these metaplastic changes was scored from (1+) to (4+) according to the extended area in all tumoral slide sections.
Results: Ciliated cell metaplasia was found in 80.4 % of benign tumors, 100 % of borderline tumors and 93.3 % of malignant tumors. Eosinophilic cell metaplasia was present in 13 % of benign tumors, 70 % of borderline tumors and 93.3 % of malignant tumors. Clear cell metaplasia was observed in 17.4 % of benign tumors, 20 % of borderline tumors and 40 % of malignant tumors. While ciliated cell metaplasia was more frequent and extensive in benign tumors, eosinophilic and clear cell metaplasias were more frequent and extensive in borderline and malignant tumors (p
Ovarian cancers, metaplastic changes, Mullerian system, ovarian carcinogenesis.