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Research Article

JCR. 2020; 7(7): 3935-3942


Fadi Mahmoud Gharib, Louay El sharkawy, Ahmed Abdelwarith Bestawy, Ahmed Naeem Eesa, Mo'men Ali Hamela.

Aim of the work: to investigate the perineural invasion (PNI) in patients with laryngeal
squamous cell carcinoma (SCC). In addition, to determine whether there is a relationship between the PNI
and the primary tumour extension, cervical nodal metastasis and distant metastasis of laryngeal SCC.
Material and methods: This study was conducted on 30 patients admitted at the otorhinolaryngology
department, Kasr-Al Ainy hospital, Cairo University suffering from laryngeal SCC in the period from
November 2016 till August 2018. Surgical resection was performed followed by histopathological
examination of the specimen to detect the presence or absence of PNI, which was then correlated to the
primary tumour extension, nodal and distant metastases. Results: 26.7% (8/30) of our patients were
pathologically proved to be PNI +ve. There was a statistical significance between PNI and the cervical
nodal metastasis (P value = 0.018); however, there was no statistical significance between the PNI and
either the primary tumour extension or the distant metastasis. Conclusion: PNI is a strong histologic
predictor of cervical nodal metastasis, which is considered a point of extreme importance while dealing
with the neck status.

Key words: Laryngeal squamous cell carcinoma; Perineural invasion; tumour extension; nodal metastasis; distant metastasis.

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