Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Research

Clinical Signifiance of Follistatin in Obese and Non-obese Egyptian Polycystic Ovarian Patients

Mostafa El-Shafey, Maghawry Hegazy, Mohammed El-Zahabi, Mohammed Farahat.

Objective: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders in women, characterized by hyperandrogenism, infertility, chronic oligo or an ovulation and obesity. In this present study we investigate the level of follistatin in obese and non-obese women with PCOS and define any correlation between follistatin and hormonal parameters. Methods: The study group included 23 obese and 17 non-obese PCOS patients. The control group included 18 obese and 22 non-obese subjects. Blood samples were obtained from the patients on day 2–5 of menstrual cycle and were assayed for Leutinizing hormone (LH), follicle stimulating hormone (FSH), total testosterone, follistatin, prolactin, sex hormone binding globulin (SHBG) and fasting insulin using enzyme-linked immunosorbent assays (ELISA), fasting glucose was measured spectrophotometry. Hemostasis model assessment - insulin resistance (HOMA-IR), free androgen index (FAI), LH/FSH ratio were calculated. Results: Follistatin concentrations were significantly higher in obese and non-obese PCOS patients (mean ± SE; 1207 ± 37.99 and 1106 ± 30.8 pg /ml respectively) than their respective controls (721.9 ± 23.44 and 653.3± 25.88pg./ml, P < 0.0001 respectively) and there was weak significant difference between obese and non-obese control P < 0.042 and weak significant difference between obese and non-obese PCOS P < 0.022 . Stepwise regression analyses for relationships between follistatin and all other variables in obese PCOS group indicated that follistatin
was negatively affected by FSH (P < 0.09), and positively affected by insulin and HOMA-IR (P < 0.009) in non-obese PCOS group. Conclusions: Serum follistatin is increased in PCOS patients compared to control subjects and there is weak significant increase in obese subjects. PCOS is the most significant variable relates to high follistatin serum concentration. Follistatin correlated negatively with FSH and a high follistatin levels may contribute to the pathophysiology of PCOS.

Key words: Follistatin; hyperandrogenism; infertility; obesity; Polycystic ovarian syndrome.

Similar Articles

Chemometric analysis of the global pattern of volatile organic compounds in the exhaled breath of patients with COVID-19, post-COVID and healthy subjects. Proof of concept for post-COVID assessment.
Zamora-Mendoza BN, Díaz de León-Martínez L, Rodríguez-Aguilar M, Mizaikoff B, Flores-Ramírez R
Talanta. 2022; 236(): 122832

Clinical Evaluation of the Rapid STANDARD Q COVID-19 Ag Test for the Screening of Severe Acute Respiratory Syndrome Coronavirus 2.
Kim HW, Park M, Lee JH
Annals of laboratory medicine. 2022; 42(1): 100-104

Prevalence of a Single-Nucleotide Variant of SARS-CoV-2 in Korea and Its Impact on the Diagnostic Sensitivity of the Xpert Xpress SARS-CoV-2 Assay.
Hong KH, In JW, Lee J, Kim SY, Lee KA, Kim S, An Y, Lee D, Sung H, Kim JS, Lee H
Annals of laboratory medicine. 2022; 42(1): 96-99

Clinical Utility of Methylation-Specific Multiplex Ligation-Dependent Probe Amplification for the Diagnosis of Prader-Willi Syndrome and Angelman Syndrome.
Kim B, Park Y, Cho SI, Kim MJ, Chae JH, Kim JY, Seong MW, Park SS
Annals of laboratory medicine. 2022; 42(1): 79-88

A case of acute-colonic pseudo-obstruction (Ogilvie Syndrome) post robot-assisted radical prostatectomy.
Tellambura M, Cumberbatch M, Goad J
Urology case reports. 2022; 40(): 101878

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.

ScopeMed Web Sites