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Review Article

J App Pharm Sci. 2016; 6(7): 189-192


Pharmacological Effects of Atorvastatin in Platelet Function and Plaque Rupture

Pushpa Natarajan, Suresh Kanna, Sinu Sahl, Pooja Sathish, Vijaya Anand.

Abstract
Platelets are a prime reason for causing cardiovascular disease (CVD). After atherosclerotic plaque rupture, platelets can form pathogenic, formation of blood clot which leads to various cardiovascular events. The beneficial effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-Co-A) reductase inhibitors reduces CVDs clinically. The objective of this review is the pharmacological benefit of atorvastatin in CVD by platelets and plaque rupture due to high levels of cholesterol.

Key words: Atorvastatin; Platelet aggregation; Platelet function; Cardiovascular disease


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