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J App Pharm Sci. 2016; 6(5): 119-123

A Study on the Adverse Drug Reactions Induced by Anti Epileptic Drugs in the Epileptic Patients

Keerthy Jayalekshmi, Kavitha Palanisamy, Sambathkumar Ramanathan, Sruthi Akela.

A research work carried for six months on epileptic patients, from April 2014 to September 2014, in a tertiary teaching care hospital, Erode. 180 epilepsy patients of both gender and all age groups undergoing treatment with only anti epileptic drugs (AEDs) were monitored for adverse drug reactions (ADRs). The drug regimen, type of seizure, gender and age group of patients were analyzed. The demographic details, case details, laboratory blood analysis, liver function tests and electrolyte profile values were collected in data entry forms.With the help of physician and previous studies, conclusions were drawn. The identified ADRs were entered in the ADR form and the causality assessment of ADRs was done using Naranjo’s scale . Monotherapy was preferred in majority of subjects. Conventiional AEDs were found to be highly utilised compared to novel drugs. Sodium valproate, Carbamazepine and Phenytoin was found induce more number of ADRs. Statistical analysis using graph pad prism version 6 was done.

Key words: Epilepsy, anti epileptic drug, adverse drug reactions.

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