Background: Liver cancer is a deadly disease and devastating public health problem globally. Natural plant products with potent growth inhibition, and apoptosis induction properties are extensively being investigated for their cancer-preventive potential. Allium ascalonicum, being an important part of the diet across various countries, possesses numerous therapeutic effects and health-enhancing properties such as cancer prevention.
Aims and Objective: To investigate anticancer activity of dry and fresh A. ascalonicum.
Materials and Methods: The organic (ethanol) extracts of dry and fresh shallot bulb (A. ascalonicum) were prepared and tested for in vitro anticancer efficacy on liver cancer cell line HepG2 by MTT (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.
Results: The results showed that both dry and fresh shallot extracts have anticancer potential with inhibitory concentration (IC50) of 50 µg/mL.
Conclusion: The plant investigated possesses remarkable anticancer activity. Further studies are essential for the isolation of lead molecules from the plant to treat liver cancer.
Key words: Allium ascalonicum; HepG2 Cell Line; MTT Assay; Anticancer Activity
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