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Study of hematological and biochemical changes in dengue fever at tertiary care hospital at Ahmedabad

Priyanka M Patel, Shilpa K Patel, Monica Arvindbhai Sabalpara, Cherry K Shah, Nailesh R Shah.

Background: Dengue viral infections are the most important mosquito-borne diseases of the Indian subcontinent and have become a major global public concern.

Objective: To evaluate hematological changes in serologically proven patients with clinical manifestations of dengue fever at tertiary care hospital.

Materials and Methods: Cases of fever, clinically suspected to be dengue were confirmed by immunochromatographic tests for dengue NS1 antigen and dengue IgM antibody during the period from September 2015 to November 2015. A total of 250 seropositive dengue cases were correlated with clinical features, hematological, and biochemical findings.

Result: With the most common clinical feature—high grade fever (95%), the main hematological findings were raised hematocrit (>29%), leukopenia (44%), and thrombocytopenia (59%).

Conclusion: Hemoconcentration, leukopenia, thrombocytopenia, raised SGPT, and raised serum bilirubin gave enough clues to test for dengue serology so as to reduce the morbidity and mortality because of this disease.

Key words: Dengue fever, dengue hemorrhagic fever, dengue shock syndrome, leukopenia, thrombocytopenia

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The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
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