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Case Report

Ann Med Res. 2015; 22(1): 44-46

Fatal Herpes Simplex Virus Infection in Darier' s Disease

Nihal Altunisik, Gulbahar Sarac, Hatice Gamze Demirdag, Mustafa Senol.

Darier disease is an autosomal dominant disorder characterized by small, hyperkeratotic papules localised on the trunk especially in the
seborrheic regions. Vegetation and infections in the intertriginous areas are common in this disease while treatment is not usually satisfying.
While the urea or lactic acid containing moisturizers, topical steroids, and topical retinoids are used in mild cases, systemic retinoids are
preferred in severe cases. Kaposi varicelliform eruption caused by herpes simplex virus is rare but a well-defined complication. Clinical
findings of this viral infection, which are usually uncommon, may delay diagnosis and treatment. Here, we report the case of a patient with
Darierís disease treated with corticosteroids who later developed fatal herpes simplex virus infection despite the aciclovir therapy.

Key words: Darier' s Disease; Herpes Simplex Infection; Fatal Herpes Simplex Infection.

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