Aim: Etiology of non-alcoholic fatty liver disease is not exactly understood. The aim of this study is to investigate the etiologic factors in patients with non-alcoholic fatty liver disease in and around Malatya, Turkey.
Material and Methods: In patients who applied to the Department of Gastroenterology, Inonu University, fatty liver was detected through hepatobiliary ultrasonography; these patients were evaluated retrospectively. Patients having over 20 gram alcohol/day in females and 30 gram alcohol/day in males were ruled out to exclude alcohol dependent fatty liver. Patients with normal liver enzyme levels and those with a two fold or higher increase were accepted as hepatosteatosis and steatohepatitis patients, respectively.
Results: A total of 112 patients 58 (51.8%) women, 54 (48.2%) men with the 43.8±11.3 years mean age were included in the study. The mean age of men was 41.8±11.3 years and the mean age of women was 45.4±11.3 years. In a total of 112 patients, we have detected hyperlipidemia in 97 (86.6%), obesity in 53 (47.3%), insulin resistance in 47 (42%), hyperlipidemia with insulin resistance in 16 (14.2%), hyperlipidemia with obesity in 27 (24.1%), obesity with insulin resistance in 35 (31.3%), and latent diabetes mellitus in 11 (31.3%).
Conclusion: Our results suggest that it is important to evaluate patients with the risk factors such as hyperlipidemia, obesity, insulin resistance regarding non-alcoholic fatty liver disease, which itself may lead to cirrhosis. Besides patients with non-alcoholic fatty liver disease should be evaluated in terms of latent diabetes.
Key Words: Non-Alcoholic Hepatosteathosis; Etiological Factors; Malatya.
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