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Original Research

Ann Med Res. 1995; 2(4): 348-353

Comparison of the effect of propofol and thiopentone on intraocular pressure during rapid anaesthetic induction.

Dr. Sıtkı Göksu*, Dr. Ünsal Öner*, Dr. Nursan Tahtacı*, Dr. İbrahim Erbağcı**, Dr. Necdet A.Bekir**




It is essential that intraocular pressure would be stable during the intraocular operations with general anaesthesia. The effects of propofol and thiopentone on the intraocular pressure were investigated on 30 patients. At first all the patients were given vecuronium 0.15 mg/kg via I V. injection. All the cases were divided in two groups.As induction agents the first group had taken propofol 2.5 mg/kg and second group thiopentone 5 mg/kg. Intarocular pressure was measured 6 times before and after the induction, /As compared with the basal values the intraocular pressure in the propofol and thiopentone group was found 8.2 % and 7.4 % high after induction. However statistical comparison of the groups was found insignificant ( p > 0 01).

The result that propofol can be used safely during ophthalmic operations especially in high intra-ocular pressure. Vecuronium and propofol may be suitable for rapid sequence induction of anaesthesia. The use of propofol can be alternative to the thiopentone.

Key words : Intraocular pressure, propofol, thiopentone, vecuronium.

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