We administered intradialytic parenteral assential amino acid (EAA) solution to 19 uremic patients with low body mass index (8M, 11 F; mean age : 48±6 years) for 3 months, undergoing hemodialysis (HD) three times per week and investigated the effects of this treatment on some nutritional parameters such as body weight (bw), body mass index (BM1), serum albumin and transferrin levels, protein catabolic rate (PCR), tuberculin skin test (PPD) and total lymphocyte counts.
Mean bw of the patients was 52±3.5 kg and HD duration was 12±4 months. Patients received same diet before and during this supplementation period (protein : lg/kg/day, energy : 35 kcal/kg/day).
Two hundred and fifty ml of EAA solution (NephrAmine)R including 12.7 g EAA was administered to each patient during the last 2 hours of each dialysis session three times per week. All patients simultaneously received 500 ml of 10% glucose.
In conclusion, we found that intradialytic parenteral EAA administration significantly increased serum albumin and transferrin levels, BM1 and PCR values without changing blood urae nitrogen levels and partially improved nutritional status. [Journal of Turgut Özal Medical Center 2(2): 155-159,1995]
Key Words : Hemodialysis, essential amino acid supplementation, chronic renal failure, malnutrition, protein catabolic rate.
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