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Ann Med Res. 1998; 5(1): 34-39

Nedocromil Sodium Worsens Ozone-Induced Lung Function Changes in Healthy Non-Smoking Subjects

H.  Canan Hasanoglu1, MD, Ghassan Noureddine2, MD, Adnan Hasanoglu3, MD, William L. Eschenbacher2, MD, FCCP  .


Ozone exposure can result in acute reversible restrictive and obstructive lung functions changes. The mechanism for these changes may be related to release of neuropeptides from sensory nerve endings in the airway. Nedocromil sodium may act by inhibiting neuropeptide release and thus could possibly prevent ozone- induced decrements in lung function. Four responders (non-smoking volunteers with >15% decline in FEVj to ozone exposure) and 5 non-responders (

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