Abstract

 

Glutathione S-transferases (GST) are jöund Ihroııghoul the hody. Il has been kııoun t hat som e disease states and hormona! manuplations change the cellular amounl of these enzymes. Iıı ıh ıs sludy. e (feci of r- HuEPO treatment on serum total GST activities
ere ınvestigated in hemodialysis patients (IH)). The patients were divided into three groups. Group-1 consisted of 15 patients havıng 2000-4000 II'
eek r-IlııFPO subcutaneously for. at least 6 months. Group-11 were 15 patients and had no r-lluFPO treatment. Group-1 II consisted of 10 patients who ııever had r-lluFPO he/öre stariing the three months' stııdy. In Group-I and -II. GST activities were ana/yzed in the beginning of the sludy. ıı hereas in Group-1 II these assays
ere performed both at the onset and in the end of three months' sludy. GST assays
ere done by the method of llabig el al. There vas no signifıcant differances between groııp-I and -II in lerms of serum total GST activities (j> 0.1) but GST activities in group-III w ere increased with r-lluFPO treatment in the end of sludy (39.04 ± ~.2 1' 1.) compared to the activities obtained at the beginning of the treatment (31.69 ± 6.6) (/> 0.03). On the other hand we could not Jind anv correlation beiween serum GST and Transaminase activities and any dıfferance between GST activities of HBs • and HBs-patients. In conlusion, r-lluFPO mav increase the level of serum GST activity with short-term treatment (3 months). but m ay gain tolerans with loııg-term r-lluFPO treatment. IJournal of Turgut Özal Medical C'enter 2(I):2X-31.1995/

Key Words : r-lluFPO, glutathione S-transferases