The effects of isoflurane and narcotics used in general anaesthesia on thyroid hormones were studied biochemically. 40 patients who were euthyroid both hormonally and clinically divided to two groups. In 1st group; induction was provided by using 5 mg/kg Na thiopenthal and 0.6 mg/kg atracrium. Anaesthesia has been maintained with 40% O2, 60% N2O, and 1.5% isoflurane. Second group was induced with 0.2 mg/kg dehydrobenzperidol, 40 pgr/kg fentanyl and 0.6 mg/kg atracrium, and maintained with 40% O2, 60% N2O, and 0.05 mg fentanyl given at 20-30 minutes intervals. Hormone levels were obtained preoperatively, immediately after induction, and postoperative 1st, 2nt, and 24th hours. T3 levels decreased at postoperative 1st hours in the first group (p
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