In this study, we compared the lipid and Lipoprotein(a) levels in patients with type 2 diabetes mellitus with the patients in the control group. A group of patients with high serum glucose and HbA1c levels was followed up for six months following medical treatment. With the normalisation of blood glucose and HbA1c levels in this period, the difference in serum Lp(a) and other atherogenic lipid levels were determLned.
Eighty patients (29 males and 51 females) with type 2 diabetes mellitus, aged 47.94 ± 7.76 years, were included in the study Patients were divided into three groups depending on HbA1c levels (< 6%, 6-8% and > 8%), Blood glucose levels were normalised at six months following treatment in 52 patients with HbA1c levels > 8%. The study was designed as a controlled and prospective study
Prior to treatment, there were no significant differences in Lp(a) levels in all of the groups. After six months, there were still no significant differences in Lp(a) and triglyceride levels. However, there was a significant decrease in total cholesterol, HDL-cholesterol and LDL-cholesterol levels. Besides, there was no correlation between HbA1c levels and all other parameters.
We conclude that there was no significant difference in Lp(a) levels in patients with type 2 diabetes and the patients in the control group. In addition, the improvement in serum glucose levels and lipid metabolsm in diabetes did not affect Lp(a) levels as the lipid profiles of our patients were similar to the characteristics of dyslipidemia in diabetes. Finally the lipid profile of patients with type 2 diabetes mellitus was also found to be affected by the regional differences in diet besides medical treatment.
Key words: Type 2 diabetes mellitus, atherosclerosis, lipoprotein(a)
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