Aim of this study was to define the difference between the effectivity of two proton pump inhibitors plus dual antibiotics therapy for eradication of Hp in patients with peptic ulcer. For this study, 44 subjets wıth documented Hp infection of the stomach were recruited. Patients were treated as follows: 1) omeprazol 20 mg bid plus amoxicillin 1gr bid plus clarithromycin 500 mg bid for one week (OAC); 2) lansoprazole 30 mg bid plus amoxicillin 1 gr bid plus clarithromycin 500 mg bid for one week (LAC). After 4 weeks upper gastrointestinal endoscopy and biopsy was repeated for histological and endoscopic evelaution. Hp eradication rates were respecti vely % 86.9 and % 90.4 in OAC and LAC groups. Both PPI-based triple therapies tested in this study were safe and effective in cur ng Hp infection. There were not any statistically signi ficant differences between two groups. OAC and LAC regimens resulted in high cure rates and thus may be considered the reatment of cho ce.
Key words: Helicobacter pylori eradication, clarithromycin, amoxicillin, peptic ulcer, proton pump nh b tors
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