Candida species are the most common causes of fungal infections in immunocompromised patients. The purpose of this study was to i nvestigate oral candidial flora and effectiveness of the prophylactic treatment in pediatric oncologic patients. Thirty four patients with haemotologic or solid malignancy enrolled in the study. The samples were taken from patient's oral mucosa and incubated in Sabouraud's agar. Isolated yeast colonies were typed with classical and disc diffusion methods. Fourteen patients had positive culture for candidiasis. The distribution of candidal species with the classical method was 11 (78,6%) C. albicans, two (14,3%) C. kefyr and one (7,1%o) C. (Torulopsus) glabrata. The disc diffusion method identified 12 (85,7%o) C. albicans and two (14,3%o) C glabrata from the specimens. The ratio of yeast colony production were 33,3%o in patients with prophylactic treatment and 44%o in patients without prophylaxis.
As a result, the follow-up of oncologic patients both with mucosal candidal culture and systemic fluconasole administration as a prophylaxis would be su table.
Key words: Pediatric oncology, oral candidiasis, prophylaxis
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