We describe a 33 year old man who presented with fatigue, weight loss, and dark brown stool. The upper gastrointestinal X-ray series and endoscopy revealed thickened gastric folds in the cardia and corpus of the stomach. Gastic juice analysis after pentagastrin stimulation and albumin levels of serum brought to mind Menetrier's disease but histopathologic examination not. We performed celiotomy and then gastrotomy. A very fragile cerebroid pattern due to thickened and irregular folds resembling cerebroid convolutions were seen along on the cardia and corpus of the stomach. These Irregular thickened mucosal folds were excised without any defect in the wall of the stomach. Histopathologic examination of the operation specimen confirmed Menetrier's disease. In the seven years since the operation the patient has had no complaint and was normal in endoscopic controls. If the giant rugae ¡n the stomach involve a limited area then a limited resection, which is described in this study, is both effective and free from the complications of the extensive gastrectomy.
Key words: Menetrier's Disease, Hypertrophic Gastropathy, Protein-Losing Gastropathy, Surgery.