Home|Journals|Articles by Year|Audio Abstracts
 

Original Research

Ann Med Res. 2000; 7(1): 24-29


The Effect of Cyclo-oxygenase Inhibition on Systemic Cytokine-Acute Phase Protein Response After Gastrointestinal Surgery

 

Sezai YILMAZ**, Vedat KIRIMLIOĞLU**, Cengiz ARA**, Ertuğrul ERTAŞ**, Mustafa BALCI*, Musa AKOĞLU*

.




Abstract


 

Objectives: Surgical operations have been shown to cause a variety of changes in cytokines and acute phase proteins. These changes can be markedly attenuated or prevented by cyclo-oxygenase inhibition. Therefore the authors assessed the effect of piroxicam treatment, having the contradictory results regarding this subject, on cytokine and acute phase protein changes after surgery.

Material and methods: The systemic cytokine and acute phase protein responses to major gastrointestinal surgery were studied in 24 patients undergoing elective gastric or rectal surgery. The patients were divided into two groups. Both groups had 12 patients and consisted of six patients undergoing subtotal distal gastrectomy and six patients undergoing low anterior resection. Piroxicam (10 mg, IM), a cyclo-oxygenase inhibitor, was administered to group II patients, but not to group I patients, 12 hour before surgery and 1 and 12 hours after surgery. Blood samples were collected 8 hour before surgery and one and five days after surgery for interleukin-6, tumor necrosis factor-a, C-reactive protein and fibrinogen determinations.

Results: Interleukin-6, tumor necrosis factor-a, C-reactive protein and fibrinogen levels in fifth postoperative day were significantly lower (p






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.