Objectives: Surgical operations have been shown to cause a variety of changes in cytokines and acute phase proteins. These changes can be markedly attenuated or prevented by cyclo-oxygenase inhibition. Therefore the authors assessed the effect of piroxicam treatment, having the contradictory results regarding this subject, on cytokine and acute phase protein changes after surgery.
Material and methods: The systemic cytokine and acute phase protein responses to major gastrointestinal surgery were studied in 24 patients undergoing elective gastric or rectal surgery. The patients were divided into two groups. Both groups had 12 patients and consisted of six patients undergoing subtotal distal gastrectomy and six patients undergoing low anterior resection. Piroxicam (10 mg, IM), a cyclo-oxygenase inhibitor, was administered to group II patients, but not to group I patients, 12 hour before surgery and 1 and 12 hours after surgery. Blood samples were collected 8 hour before surgery and one and five days after surgery for interleukin-6, tumor necrosis factor-a, C-reactive protein and fibrinogen determinations.
Results: Interleukin-6, tumor necrosis factor-a, C-reactive protein and fibrinogen levels in fifth postoperative day were significantly lower (p
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