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Ann Med Res. 1994; 1(1): 10-13

The effect of hiperperistaltism induced by neostigmine to the formation of peritoneal adhesions

Dr. Mustafa Erbilen1, Dr.A.Süha Sönmez2, Dr.Adnan Arab1, Dr.Mustafa Şahin1, Dr.Ertuğrul Ertaş1, Dr.Ertan Bülbüloğlu1




Twenty Wistar rats were anaesthetised with ketamine chloride and the abdomen was opened through a midline incision 3 cm long. Omentum was tied with silk suture in one part. At 3 cm right of the midline, 4x1 cm of defect including muscle and underlying peritoneum was performed. This defect was sutured by 3-0 silk from 5 sides. One cm2 erosion was formed on anterior surface of the caecum by brushing. Then, rats were separated into two groups.25 µgr/kg/im/day neostigmine was administered to study group for 7 days. All rats were sacrified and evaluated at the postoperative tenth day. There was significant difference between the control and neostigmine (p < 0.05). It is suggested that the provocation of peristaltism may be effective in preventing postoperative peritoneal adhesions. [Journal of Turgut Özal Medical Center 1(1):10-13,1994]

Key Words : Neostigmine, peritoneal adhesion

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