Abstract

 

Purpose:After more than a century of intensive research preeclampsia and eclampsia remain an enigmatic set of conditions. Interaction between placental and maternal tissue is probably the primary cause, but the exact nature of the divergences from normal pregnancy remain unclear. Since there are some important alterations in lipid metabolism due to pregnancy, this study was undertaken in order to evaluate the serum lipid and Lp(a) changes in preeclampsia.

Materials and methods:The study population was comprised of 35 patients with preeclampsia according to clinical findings of proteinuria and high blood pressure (>140 / 90) values compared to 35 normal pregnant women as control. Both groups were matched by maternal age, gestational period, blood pressures, and body mass index as well as lipid parameters. Serum total-C, HDL-C, ve TG levels were analised in Olympus AU 600

otoanalysor with enzimatic-calorimetric methods, and Lp (a), apo A-I ve apo B levels were analysed by Boehring nephelometer-100 analiyser with nepholometric method.

Results:The lipoprotein profiles of the groups showed that serum HDL-C, total cholesterol, and triglyceride levels were significantly elevated in preeclampsia (58 ± 10; 254 ± 47 and 259 ± 66 respectively) compared to normal pregnant women (46 ± 8; 219 ± 57; and 198 ± 49 respectively ) (p