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Original Research

Ann Med Res. 2002; 9(1): 5-9

Investigation of In Vitro Superoxide Scavenging Capacityof Cape

Kadir Batçioglu*, I. Çetin Öztürk**




Introduction: The antioxidant capacity of CAPE (caffeic acid phenethyl ester) has been investigated in recent

years but, so far most of the studies were in vivo studies. In this study we investigated, the in vitro antioxidant

capacity of CAPE to scavenge superoxide radicals. CAPE, an active component of propolis from honeybee

hives, is known to have anti mitogenic, antioxidant, anticarcinogenic, antiinflammatory and immunomodulatory


Aim of the study: CAPE is an antioxidant molecule in vivo. The aim of this study is to investigate if CAPE under

in vitro conditions has the same effect similar to in vivo.

Methods: The method developed by McCord and Fridovich for the determination of SOD activity is modified by

replacing SOD with CAPE.

Results: We find that, CAPE has superoxide scavenging capacity in a dose dependent manner. The presence of

50 μmol/L CAPE caused 73.66 % percentage of inhibition in cyt c reduction.

Key Words: CAPE, Superoxide scavenging capacity, Oxidative stress.

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