Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Research

Effect of long-acting beta-2 agonists on small airways among patients with chronic lower respiratory symptoms - A clinicospirometric evaluation

Sujoy Mukherjee, Goutam Banerjee, Anil Baran Singha Mahapatra.

Background: Long-acting beta-2 agonists (LABA) are recommended for regular use to control chronic lower respiratory symptoms (LRS). However, LABAs may have the potency to modulate the lung pathology by suppressing the ongoing bronchial inflammation, leaving such patients at greater risk of severe complications.

Aims and Objectives: The aim of this study was to evaluate the effect of inhaled LABA medications on small airways in patients with chronic LRS by spirometric screening at a tertiary hospital.

Materials and Methods: A total of 240 urban patients (aged 25–50 years; both genders) with LRS referred from outdoor patients for spirometric screening were included in this study. After obtaining detailed clinical profile, patients were divided into two groups based on inhaled medications history: Lone LABA users (n = 130) and combined bronchodilator (BDRs) regimen (LABA + inhaled corticosteroids) users group (n = 110). Spirometry was carried out following recommendations of the American Thoracic Society/European Respiratory Society (2005). Patients were categorized based on forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, FEF25–75%, and peak expiratory flow rate values.

Results: A study revealed that those patients were treated with lone LABA inhalers chronically, persistence of small airways obstruction was significantly higher in them compared to combined BDRs regimen user group.

Conclusion: The present study explores better efficacy of combined usage of combined BDRs regimen and potential masking effect of lone LABA in small airway diseases with respect to clinicospirometry study.

Key words: Long-acting Beta-2 Agonists; Small Airways Obstruction; Spirometry

Similar Articles

Insufficient ventilation led to a probable long-range airborne transmission of SARS-CoV-2 on two buses.
Ou C, Hu S, Luo K, Yang H, Hang J, Cheng P, Hai Z, Xiao S, Qian H, Xiao S, Jing X, Xie Z, Ling H, Liu L, Gao L, Deng Q, Cowling BJ, Li Y
Building and environment. 2022; 207(): 108414

Long non-coding RNA MEG3 regulates autophagy after cerebral ischemia/reperfusion injury.
Li TH, Sun HW, Song LJ, Yang B, Zhang P, Yan DM, Liu XZ, Luo YR
Neural regeneration research. 2022; 17(4): 824-831

Guiding RNAi Design Through Characterization of Endogenous Small RNA Pathways.
Peter JO, Santos-Ortega Y, Flynt A
Methods in molecular biology (Clifton, N.J.). 2022; 2360(): 33-47

Super-Resolution Imaging of the Actin Cytoskeleton in Living Cells Using TIRF-SIM.
Wöllert T, Langford GM
Methods in molecular biology (Clifton, N.J.). 2022; 2364(): 3-24

The Current Status of Drug Discovery for the Oxytocin Receptor.
Nashar PE, Whitfield AA, Mikusek J, Reekie TA
Methods in molecular biology (Clifton, N.J.). 2022; 2384(): 153-174

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.

ScopeMed Web Sites