Relatıon Of Hbv-DNA Levels Between Serum Alanin Aminotransferases And Serologıc Markers Of HBV
Serpil Kaya*, Ãzlem YÃ¶nem**,Â Levent Ãzdemir***, Zeynep SÃ¼mer*.
Objective: We aimed to determine the relationship between serum HBV-DNA levels andÂ serumÂ alanine aminotransferase (ALT) levelsÂ in different age and sex groups.
Materıal And Methods: Serum HBV-DNA levels of 90 patients with chronic HBV infection and serum alanine aminotransferase (ALT) levels were evaluated according to their age andÂ sexÂ retrospectively.
Results: HBV-DNA levels of these patients were grouped as 1-5 pg/mL in 8.9%, 5-100 pg/mL in 45.6%, 101-2000 pg/mL in 27.8%, Â³2000 pg/mL in 17.8%. ALT levels were grouped as â¤40 U/L in 26.7%, 41-60 U/L in 17.8%, 61-80 U/L in 13.3%, 81-100 U/L in 10.0%, >100U/L in 32.2% of the patients. There was a correlationÂ between HBV-DNAÂ and age. There were no a statistically significant difference between sex and age, serum HBV-DNA levels and serum ALT levels. Statistical significance were obtained between HBe antigenemi and age and serum HBV-DNA levels.
Conclusion: Our results suggested that HBe seroconversion does not accurately determine infectivity and HBV- DNA levels may be very useful in diagnosis, therapy and follow-up periods of chronic HBV infection.
Key Words: Hepatitis B Virus, HBV-DNA, HBe Antigen, Alanine Aminotransferase