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Ann Med Res. 2007; 14(2): 85-89

The Effects of Fentanyl or Morphine Added to Intrathecal Bupivacaine in Spinal Anesthesia for Cesarean Section


Fatih Uğur*, Aliye Esmaoğlu*, Tamer Güneş**, Nebahat Gülcü***, Adem Boyacı*




Background: The present study was undertaken to compare the efficacy and safety of hyperbaric bupivacaine with 20mg fentanyl or 0,1 mg morphine for spinal anesthesia in patients undergoing cesarean section.

Material and Methods: Forty patients were included in the study. They were allocated to receive either 0,5% 10 mg bupivacaine with 20mg (0,5cc) fentanyl (Fentanyl Group) or 0,5% bupivacaine with 0,1 mg (0,5cc) morphine (Morphine Group). Spinal anesthesia was performed using 25 G needle at the L3-4  or L4-5  interspace.

Results: The times from intrathecal injection to the start of surgery, end of surgery, two  segment regression, and complete recovery of sensation and motor power were not different among the groups. The incidences of nausea, vomiting and  hypotension were similar in groups. In respect of intraoperative analgesia the groups were similar but postoperative vomiting was significantly higher in Morphine Group. Neonatal condition, as evaluated by the Apgar’s scores at 1 and 5 min, and umbilical venous and arterial blood gases were excellent in the two groups.

Conclusion: The intraoperative analgesia achived with intrathecal bupivacaine plus fentanyl was similar to that in the case of bupivacaine plus morphine. Both drugs can be used effectively and safely in the cesarean operations.

Key Word: Cesarean section, Intrathecal, Fentanyl, Morphine

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