Isotretinoin is a synthetic retinoid which is a derivative of vitamin A and is often used in the treatment of acne. In vivo and invitro studies revealed that systemic retinoids have shown virucidal activity by reducing HSV-1 replication and have been used for the treatment of recurrent herpes infections. However, some articles have reported that herpetic infections can be triggered during isotretinoin treatment. The prevalance of HSV-1 has been rising among genital herpes enfections due to increasing sexual diversity and autoinoculation. In the literature, any development of genital herpes infection during the isotretinon treatment has not been reported. In this article, a 17 years old male patient who developed herpes genitalis 15 days after the beginning of 40 mg/day isotretinoin for the treatment of nodular acne vulgaris, is presented.
Key Words: Isotretinoin, Herpes Genitalis
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