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Ann Med Res. 2009; 16(3): 163-167

The Effect of Factor XIII V34L Polymorphism in Obstructive Sleep Apnea Patients


Nadir Koçak*, Filiz Özen**, Taha Bekçi***




Aim: In the Obstructive Sleep Apnea Syndrome (OSAS), the organism is exposed to hypoxic effects. Chronic hypoxia has thrombotic, vasoactive and inflammatory effects on cardiovascular system. This triggers the processes progressing to cardiovascular disease. While the pathological effects to which the patients are exposed are the same, marked differences are observed between patients in the progression of OSAS. Individual protective factors are thought to be effective in the development of these differences. In  some studies, it was reported that the Val34Leu polymorphism of Factor XIII, which is also known as fibrin-stabilizing factor, might have a protective effect against cardiovascular diseases. In the light of these studies, we aimed to investigate whether this polymorphism has any effects on the development of the differences in the progression of the OSAS patients.

Materials and Methods: The patient group was selected from patients admitted to the our Sleep Laboratory. Total 119 of subjects, 44 OSAS patients, 32 OSAS patients with cardio vascular diseases (CVD) and 43 controls were enrolled in the study. The control group consisted of healthy volunteers who had no symptoms of OSAS and scored 0 on the Epworth sleepiness scale. In order to determine gene mutations, DNA isolation was performed from peripheral blood samples. Data were analyzed by SPSS 15.0 package program.

Results: While mean weight and BMI were significantly different, no significant differences were found between patient and control groups in terms of FXIII Val34Leu allele distributions.

Key Words: Obstructive Sleep Apnea, Polymorphism, Mutation

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