Home|Journals|Articles by Year|Audio Abstracts RSS - TOC
 

Original Research

Ann Med Res. 2011; 18(4): 240-247


Effects of Erdostein Use in Pregnancy on Fetal Rat Lung Maturation

  Önder Koç*, Bülent Duran*, Ata Topçuoğlu*, Tülin Fırat**,  Aysel Kükner**, Melahat Dönmez*.




Abstract

 

Objective: This study was planned for investigating the probable effects of 2 and 4 mg erdostein use on fetal lung maturation

Materials and Methods: Wistar-Albino pregnant rats were divided into 3 groups as group I (n=10): SHAM; group II (n=10): Erdosteine 2mg, group III (n=10):Erdosteine 4 mg. The medication were given orally to pregnant rats at the end of first week and continued until the day of fetus excision by laparotomy at day 13 or day 18. Following the delivery, birth weight, crown-rump length, weight of whole lung were measured. The maturation of lungs were evaluated histopathologically. Fetuses were grouped according to the developmental stages of lungs.

Results : There were no significant differences in birth weight and crown-rump length between the group I, II and III for the fetuses of day 13. Only whole lung weights of group III was significantly higher compared to group I (p






Full-text options


Share this Article



Online Article Submission
• ejmanager.com
• ojshosting.net




eJManager.com
Review(er)s Central
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.