Aim: Diazepam and midazolam are widely used medicines in neurological illnesses and there are some side effects which have been observed with chronic usage of these medicines. The interaction of these medicines with trace elements during metabolisation has vital importance. Trace elements have an important role on diseases and health. For this reason, rats were exposed to diazepam and midazolam and carrriers of these medicine and determination of the change in trace elements levels was aimed in this six-week study. Material and Methods: Diazepaman and midazolam, respecitevely in 1mg/kg and 0.75 mg/kg doses, were given intraperitonally twice a day for six weeks. Trace element levels taken from the blood serum samples after giving the medicine were analyzed by SEM-EDX. The levels of 32 trace elements were determined and major differences were observed between control, carriers and experimental groups. In diazepam group, K, Fe, Cu, Zn, Se, Sb, Hg, Pb, Mn, Zr, In and Bi elements and in carriers group, Na, K, Mo , Zr, Ag and In elements were found to reveal statistically meaningful decreases. K, Mo, Zr, Ag and In elements for midazolam group and Na, K, Mo, Ag and In elements in carriers group display a statistically meaningful decrease compared to control group.
Results: Chronic usage of Diazepam and Midazolam causes change in serum trace elements levels and these vital levels must be observed when these medicines are used.
Key Words: Diazepam; Midazolam; SEM-EDX; Trace Element.
|
