The chemical investigation of the crude extract from the solid state fermentation of Aspergillus japonicus, an endophytic fungus harboring leaf of Garcinia preussii, by means of LC-MS led to the isolation of two compounds, variecolin (1) and neovasifuranone B (2) from the cyclohexane fraction. Their structures were elucidated on the basis of spectroscopic analysis and by comparison of its spectral data with those reported in the literature. The antimicrobial studies showed that the isolated compounds exhibits antibacterial activity
Key words: Garcinia preussii, Aspergillus japonicus, ophiobolin, antibacterial
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