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Original Article

J App Pharm Sci. 2016; 6(6): 008-011


Physalis minima Linn Methanolic Extract Reduces Blood Glucose Level without Compromising Sperm Quality in Normoglycaemic Mice

Dzulsuhaimi Daud, Siti Fatimah Elias, Fatimah Sarah Mohamad Hassan, Mohammad Noor Jalil, Alene Tawang.

Abstract
Effects of Physalis minima Linn (PML) methanolic extract on blood glucose level and sperm quality of normoglycaemic mice have been investigated. Twenty four ICR male mice were randomly assigned to four groups and fed with maintenance diets (commercial rat chow, 5 g/head/day and water ad-libitum). Group A (n=6) served as a control and received additional 2 ml/kg bodyweight (bwt) of distilled water, Group B (n=6) was supplemented with 50 mg/kg bwt of PML, Group C (n=6) was supplemented with 100 mg/kg bwt of PML and Group D (n=6) was supplemented with 200 mg/kg bwt of PML. Bodyweight and blood glucose level were monitored on a weekly basis. After four weeks of treatment, all animals were sacrificed by cervical dislocation and their epididymis was collected and subjected to sperm analysis. Bodyweight was increased (p0.05) were observed between treatments. Blood glucose was decreased significantly (p

Key words: Physalis minima, sperm quality, blood glucose, diabetes mellitus



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