Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Article

J App Pharm Sci. 2016; 6(2): 172-174

Determination of antidiabetic compounds from Helicteres isora fruits by oral glucose tolerance test

Govindasami Chandirasegaran, Chakkaravarthy Elanchezhiyan, Kavisa Ghosh, Subramaniyan Sethupathy.

The aim of this study was to analyze compounds from the methanolic extract of fruits of Helicteres isora for antidiabetic activity. Sanguinarine, berberine chloride (BC) and muscimol were found to be as major compounds in the methanolic fruits extract of H.isora. BC was isolated from the methanolic fruit extract of H. Isora by using HPLC and other compounds were commercially acquired. Diabetes was induced in rats by a single dose of intraperitonial injection of streptozotocin (STZ). Sanguinarine (50 mg/kg b.w), BC (50 mg/kg b.w) and muscimol (50 mg/kg b.w) were evaluated by Oral Glucose Tolerance Test (OGTT) in normal and STZ induced diabetic rats. Among the three compounds, BC significantly reduced the blood glucose levels when compared to sanguinarine and muscimol. The OGTT study clearly indicates, BC possess promising antidiabetic activity against STZ induced diabetic rats.

Key words: Helicteres isora, Diabetes, Sanguinarine, Berberine chloride and Muscimol

Full-text options

Full-text Article

Share this Article

Readers of this article also read the following articles
»Study of potential drug–drug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region
»Biochemical effects of Calotropis procera on hepatotoxicity
»Career in Medicine: What factors influence medical students?
»Pulmonary hypertension due to lithium therapy: a case report
»Evaluation of Patellar Position before and After Medial Opening Wedge High Tibial Osteotomy: Radiographic and Computed Tomography Findings
»Assessment of mental health in medical students of GMERS Medical College, Patan, Gujarat
»Myeloperoxidase, Malondialdehyde and serum Lipids in type 2 diabetes mellitus
»The efficacy of rib cage mobilization on lung function in COPD patients

Journal of Interdisciplinary Histopathology


BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.