The 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2 methoxybenzamide hydrochloride monohydrate exhibits antiemetic and parasympathomimetic activity. Density (Ļ) and refractive index (nD) measurements were carried out as a function of drug concentration (c=0.01-0.11 molL-1 ) in aqueous NaCl/LiCl (c=0.05, 0.10 and 0.15 molL-1 ) solutions at 30 °C. Linear relation of concentration dependence of density and refractive index were studied. Molar refractivity (RM) of solution was calculated from density and refractive index data and polarizability (Ī±) was calculated from molar refractivity data. Stronger polarizability effects have been observed K with increase in drug concentration.
Density, Physicochemical properties, Molecular interactions, Polarizability