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Original Article

Development and Validation of Spectrophotometric Method for Determination of Gabapentin in Bulk and Pharmaceutical Dosage Forms Based on Schiff Base Formation with Salicylaldehyde

Ihab M Almasri, Mai Ramadan, Eman Algharably.

A sensitive, simple and economic spectrophotometric method was developed and validated for the determination of gabapentin in pure form and pharmaceutical preparations. The method is based on Schiff base condensation reaction of the primary amino group of gabapentin with salicylaldehyde reagent in presence of acetate solution at 45ᵒC for 20 mins. The obtained yellow colored derivative in methanolic medium showed absorption maxima at 403 nm. Under the optimum conditions, Beers law was obeyed in the concentration ranges of 6 to 100 μg/mL with correlation coefficient value of 0.9961. Limit of detection and limit of quantification were found to be 1.16 and 3.48 μg/mL, respectively. The validity of the described method was assessed according to the ICH guidelines. The mean percentage recoveries standard deviation were 100.57 1.5 by applying the standard addition technique. The method was repeatable and precise (relative standard deviation ≤ 0.61% and ≤ 1.34%, respectively) and was successfully applied for determination of the investigated drug in its pharmaceutical dosage form without detectable interference from the additives, hence can be suggested for routine analysis of gabapentin.

Key words: UV-Vis, spectrophotometric, derivatization, gabapentin, salicylaldehyde.

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