OBJECTIVES: To determine the relationship of total cholesterol, HDL-C and their ratio among ischemic and hemorrhagic stroke
STUDY DESIGN: An observational prospective comparative study.
PLACE AND DURATION: This research work was carried out from 1st June 2014 to 31st December 2014 at department of medicine Bahawal Victoria Hospital Bahawalpur
METHEDOLOGY: Hundred patients between 30 to 90 years of age, who were admitted by the department of general medicine BVH Bahawalpur with first ever stroke and verified by CT scan brain , were included in the study. Patients who had history of coronary heart disease or lipid lowering drugs, neurological deficits secondary to epilepsy, infective or metastatic disorder, or pre-existing severe cognitive disorder were excluded from this study. A detailed history and physical examination details along with fasting lipid profile were collected from patient records in the hospital medical department. Mean values of quantitative data were presented as mean SD (standard deviation).Frequency percentage of total cholesterol, high density lipoproteins and triglycerides in both groups of ischemic and hemorrhagic stroke, were determined and compared using proportion test for any significant difference taking p-value of < 0.05 as significant.
RESULTS: Quantitative data of CVA, comprising (50 each of ischemic and hemorrhagic cases) was analyzed. Mean age of presentation was 56 years. In 50 ischemic patients mean total cholesterol was raised above normal reference range. It was 218.30±79mg/dl in ischemic stroke while it was 194±26.7mg/dl in hemorrhagic cases and it was highly significant at P value of < 0.001.The mean HDL concentration was 33.10 -7.33 in patients of ischemic stroke while it was 39.02-4.22 in hemorrhagic cases with p value of o.oo2 (highly significant). Serum triglycerides levels turned out to be normal in both groups.
CONCLUSION: Hypercholesterolemia and low HDLC was seen significantly in ischemic CVA group as compared to hemorrhagic counterpart.
Ischemic stroke, Hemorrhagic stroke, Serum lipid profile