Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Research

Comparative Studies on the Effect of High Fish and Corn Oil Diet on Lipid Profiles, PPAR-a and FAS mRNA in Swiss Mice

Tamer A Ismaeil, Mohamed M Hussein, Mohamed Mohamed Soliman, Abdulrahman A Alhumiany.

Background: The hypolipidemic actions of oils reflect their quality and safety for human health. PUFA include omega 3 and omega 6, considered to be essential fatty acids. Eicosapentaenoic acid (EPA, 20: 5 n-3) and docosahexaenoic acid (DHA, 22: 6 n-3) are two important long-chain unsaturated FA in essential omega 3 family and are found mainly in fish oil, while arachidonic acid (20 : 4 n-6) is a member of omega 6 family found mainly in plant oils.
Objective: The current study was conducted to test the lipidemic effects of two oil supplements and genes expression related to lipid metabolism.
Methodology: Experimental mice were fed on normal diet and foods enriched in corn oil or fish oil for one month. Lipid profiles were measured and gene expression of PPAR-α and fatty acid synthase were semi-quantitated using RT-PCR analysis.
Results: The current study revealed a significant increase in lipid profiles in corn oil fed group. LDL-c and blood glucose were decreased while HDL-c was significantly increased (p

Key words: Corn oil, Fish oil, FAS and PPAR-α expression, Mice

Share this Article

Oxidants and Antioxidants in Medical Science


BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.