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Comparative Studies on the Effect of High Fish and Corn Oil Diet on Lipid Profiles, PPAR-a and FAS mRNA in Swiss Mice

Tamer A Ismaeil, Mohamed M Hussein, Mohamed Mohamed Soliman, Abdulrahman A Alhumiany.

Abstract
Background: The hypolipidemic actions of oils reflect their quality and safety for human health. PUFA include omega 3 and omega 6, considered to be essential fatty acids. Eicosapentaenoic acid (EPA, 20: 5 n-3) and docosahexaenoic acid (DHA, 22: 6 n-3) are two important long-chain unsaturated FA in essential omega 3 family and are found mainly in fish oil, while arachidonic acid (20 : 4 n-6) is a member of omega 6 family found mainly in plant oils.
Objective: The current study was conducted to test the lipidemic effects of two oil supplements and genes expression related to lipid metabolism.
Methodology: Experimental mice were fed on normal diet and foods enriched in corn oil or fish oil for one month. Lipid profiles were measured and gene expression of PPAR-α and fatty acid synthase were semi-quantitated using RT-PCR analysis.
Results: The current study revealed a significant increase in lipid profiles in corn oil fed group. LDL-c and blood glucose were decreased while HDL-c was significantly increased (p

Key words: Corn oil, Fish oil, FAS and PPAR-α expression, Mice



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