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Original Article

J App Pharm Sci. 2025; 15(4): 262-273


Factors affecting mortality in diabetic foot ulcer infection patients in national referral hospital, Jakarta, Indonesia: 4-year cross-sectional study

Fitrianingsih, Putu Rika Veryanti, Em Yunir, Agusdini Banun Saptaningsih, Rani Sauriasari.



Abstract
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Diabetic foot ulcer infection (DFUI) is a frequent complication among diabetic patients, with the highest mortality rate worldwide. This study aims to identify factors that affect mortality in DFUI patients. The cross-sectional study was conducted at Cipto Mangunkusumo Hospital (RSCM), Jakarta, Indonesia. Medical records of 259 DFUI inpatients were collected from January 2019 to December 2022. The patient outcome observed was mortality. Most of the DFUI patients were women (52.1%), with Type 2 Diabetes Mellitus (T2DM) (98.5%), with a mean age of 59.65 ± 10.83 years and a duration of DM of 9.03 ± 7.29 years. The mean BMI was 24.85 ± 4.95 kg/m2, with 38.6% of patients smoking. Comorbidities included hypertension (51.4%), peripheral artery disease (51.4%), dyslipidemia (34.7%), and CAD (14.3%). The majority (64.1%) had severe infection. Severe infection and CAD both elevated mortality risk by 5.202 times (95% CI, 1.397–19.375) (p = 0.014) and 5.578 times (95% CI, 2.037–15.272) (p =

Key words: Amputation; Diabetic foot ulcer infection; Factor; Mortality; Outcome







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