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Association of thyroid disorders in females with primary infertility attending a tertiary-care hospital in northeast India

Chandan Nath, Happy Chutia, Alice Abraham Ruram, Akash Handique, Ananya Das.


Background: A close interconnection is present between hypothyroidism and hyperprolactinemia. Failure to ovulate regularly in women of the reproductive age group may occur owing to hypothyroidism.

Objective: To look for thyroid disorders among the primary infertile group of female patients and to see the association of serum prolactin level and thyroid-stimulating hormone (TSH) level, if any.

Materials and Methods: In this study, we investigated 53 diagnosed female subjects of primary infertility who were sent to the Department of Biochemistry for hormonal investigation. Fifty-three fertile age-matched females were enrolled for the study as control subjects. Serum prolactin and the TSH levels were measured by using chemiluminiscence method (Access 2, Beckman Coulter).

Result: Significantly higher prolactin and TSH levels were found among cases when compared with control subjects. A positive association was found between TSH and prolactin levels among the primary infertile female subjects.

Conclusion: This study showed significantly higher prolactin and TSH levels among the primary infertile female patients. Therefore, for proper management of infertile cases, it may be necessary to look for thyroid dysfunction and treat it accordingly.

Key words: Infertility, prolactin, thyroid hormones, TSH

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