Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Mini Review



Critical Roles of Thiol-Mediated Antioxidant Detoxification Systems in the Pathophysiology of Plasmodium falciparum-Infected Erythrocytes

Paul C Chikezie.

Abstract
Five species of intracellular protozoa of the genus Plasmodium cause malaria in human. The present review briefly highlighted the critical roles of thiol-mediated antioxidant detoxification systems in the pathophysiology of Plasmodium falciparum-infected erythrocytes that are required for the survival of the malarial parasite in hyperoxidative intracellular environment. Scientific search engines such as PubMed, Pubget, Medline, EMBASE, Google Scholar, ScienceDirect and SpringerLink were used to retrieve online publications from 1976 to 2015. Haemoglobin molecules that are taken up by the parasites’ acid food vacuoles lead to the spontaneous oxidation of haem iron from Fe2+ to Fe3+, formation of superoxide radicals (O2•âˆ’), and subsequently, hydrogen peroxide (H2O2) and hydroxyl radicals (•âˆ’OH), which are highly reactive and cytotoxic oxygen intermediates. Additionally, toxic haem (ferri/ferroprotoporhyrin IX (FPIX) that is released upon haemoglobin digestion is biomineralized to form inert haemozoin. P. falciparum reduced glutathione (PfGSH) is a cofactor for glutathione enzyme systems and mediates in direct reductive detoxification of the toxic byproduct of haemoglobin digestion-FPIX. The postulated role of P. falciparum glutathione S-transferase (PfGST) in the development of drug resistance in malarial parasites is still being controversially discussed. However, selective inhibition of PfGST and P. falciparum thioredoxin reductase (PfTrxR) identifies novel drug targets and potential chemotherapeutic strategy to combating malaria.

Key words: Erythrocyte; ferri/ferroprotoporhyrin IX; glutathione; thioredoxin; Plasmodium falciparum



Similar Articles

Markers for Mitochondrial ROS Status.
Ostaszewska-Bugajska M, Podgórska A, Szal B
Methods in molecular biology (Clifton, N.J.). 2022; 2363(): 199-213

Effects of hydrogen water treatment on antioxidant system of litchi fruit during the pericarp browning.
Yun Z, Gao H, Chen X, Chen Z, Zhang Z, Li T, Qu H, Jiang Y
Food chemistry. 2021; 336(): 127618

Complications of Sub-microscopic Plasmodium vivax Malaria among Orang Asli in Pos Lenjang, Kuala Lipis.
Mat Salleh NH, Abdul Rahman MF, Samsusah S, De Silva JR, Tan JH, Amir A, Lau YL
Tropical biomedicine. 2021; 38(1): 33-35

Differential Effect of Antioxidants Glutathione and Vitamin C on the Hepatic Injuries Induced by ANKA Infection.
Kauffmann N, da Penha LKRL, Braga DV, Ataíde BJA, Mendes NSF, de Sousa LP, da Souza GS, Passos ACF, Batista EJO, Herculano AM, Oliveira KRHM
BioMed research international. 2021; 2021(): 9694508

Relationship between GSTM1 and GSTT1 polymorphisms and HPV infection: a systematic review.
Bortolli APR, Vieira VK, Stefanski EE, Lazarotto AK, Lucio LC
Molecular biology reports. 2021; ():


Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Covid-19 Trends and Statistics
ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.



ScopeMed Web Sites