Home|Journals|Articles by Year|Audio Abstracts

Brief Report

Immediate postpartum depression and the NT-3 gene

Valeria Velazquez Jaramillo, Arturo Gonzalez Santana, Araceli Consuelo Hinojosa Juarez, Joel Alberto Vargas Hernandez, Hugo Mendieta Zeron.

Cited by 0 Articles

Introduction: Postpartum depression has a prevalence range from 6.5% to 12.9%. The NT-3 gene is involved in alterations in patients with mood disorders. Purpose: The aim was to describe a possible correlation between the NT-3 expression and the Edinburgh Postnatal Depression Scale (EPDS). Material and Methods: It was a clinical, comparative, prospective and cross-sectional study. Puerperal women were asked to answer the EPDS while mRNA was extracted from peripheral blood and through the qPCR the relative expression of NT-3 was determined using the delta-delta- (CT) method (2-ΔΔCT). Results and Discussion: The NT-3 expression was quantified in 5 patients with depression and 6 healthy women. A fold change of 1.7 was obtained when the NT-3 is present in the group with depression in relation to the control group. Also, a positive significant correlation was found between the gene relative expression and the EPDS score (r2 = 0.60516, p = 0.04853). The fold change when the NT-3 is expressed means a risk to develop puerperal depression in our population, which is visualized as an inevitable disease for a wide range of patients. Conclusion: It was concluded that the NT-3 gene is effectively correlated with the EPDS score and explains, in part, a subgroup of patients that will develop this health complication.

Key words: Edinburgh Postnatal Depression Scale, NT-3, postpartum depression

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

ejPort - eJManager.com
Refer & Earn
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.