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Original Article

J App Pharm Sci. 2016; 6(3): 107-110

Antidiarrhoeal and antioxidant properties of ethanol leaf extract of Pseudocedrela kotschyi

Grace Akanimo Essiet, Akuodor Godwin Christian, Aja Daniel Ogbonna, Megwas Anthony Uchenna, Ekenjoku John Azubuike, Nworie Emmanuel Michael.


This study was carried out to establish the antidiarrhoeal and antioxidant properties of the ethanol leaf extract of Pseudocedrela kotschyi in wistar albino rats. The effect of the ethanol extract on castor oil induced diarrhoea, motility of the GIT using the charcoal plug method and castor oil induced intestinal fluid accumulation in rats were evaluated. The antioxidant potential of the leaf extract was investigated by measuring its capability for scavenging 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical. The phytochemical constituents and the oral acute toxicity of ethanol leaf extract were also determined in rats. Generally, the ethanol leaf extract at all doses used, was found to posses significant (P

Key words: Antidiarrhoeal; Antioxidant; Pseudocedrela kotschyi; Leaf extract; Rats

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