It is necessary to quantify the relationship between pregnancy outcomes and epilepsy and antiepileptic medication exposure. To look into the relationship between epilepsy and reproductive outcomes, and whether or not antiepileptic medication exposure was involved, this systematic review was conducted. This review was conducted following PRISMA guidelines. Hence, studies that discussed the newborn and maternal outcomes of mothers with epilepsy, were published between the years 2011 and 2024 and were searched using electronic databases including MEDLINE, Cochrane, AMED, and Embase, without regard to language limitations. Fourteen articles totaling 3,177,752 participants (16,647 with epilepsy and 3,161,105 without epilepsy) were included in the systematic review; twelve of the included studies discussed both maternal and neonatal outcomes, one study focused solely on neonatal outcomes, and one study solely on maternal outcomes. It was found that there is a correlation between epilepsy, antiepileptic medication exposure, and unfavorable outcomes for the mother, newborn, and infants during pregnancy.
Key words: Epilepsy, pregnancy, neonatal outcome, maternal outcome, systemic review
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